Percocet is a prescription medication that combines Oxycodone (10 mg) and Acetaminophen (325 mg). Oxycodone: A strong opioid pain reliever. Acetaminophen: A milder pain reliever and fever reducer that enhances oxycodone’s effect. Percocet is primarily used for moderate to severe pain that cannot be managed by non-opioid medications alone. Uses Percocet 10/325mg is prescribed for: Post-surgical pain Injury-related pain Severe chronic pain (when other medications are insufficient)